Regional analysis of intact and defective HIV proviruses in the brain of viremic and virally suppressed people with HIV
TA Angelovich, CR Cochrane, J Zhou… - Annals of …, 2023 - Wiley Online Library
TA Angelovich, CR Cochrane, J Zhou, C Tumpach, SJ Byrnes, J Jamal Eddine, E Waring…
Annals of Neurology, 2023•Wiley Online LibraryHere, we provide the first regional analysis of intact and defective HIV reservoirs within the
brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH)
harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and
cerebellum relative to frontal white matter. Intact proviruses were primarily found in the
frontal white matter but also detected in other brain regions of PWH, demonstrating frontal
white matter as a major brain reservoir of intact, potentially replication competent HIV DNA …
brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH)
harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and
cerebellum relative to frontal white matter. Intact proviruses were primarily found in the
frontal white matter but also detected in other brain regions of PWH, demonstrating frontal
white matter as a major brain reservoir of intact, potentially replication competent HIV DNA …
Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798–802
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